#1000 mcg of b12 trial#

2019 9:625‐630.What Are Vitamins | Nutrient-Dense Foods | Fat-Soluble Vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency.

Bensky MJ, Ayalon-Dangur I, Ayalon-Dangur R, Naamany E, Gafter-Gvii A, Koren G, Shiber S.

Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency.

Vidal-Alaball J, Butler C, Cannings-John R, Goringe A, Hood K, McCaddon A, McDowell I, Papaionnou A.

Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms. Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults.

Rajan S, Wallace JI, Brodkin KI, Beresford SA, Allen RH, Stabler SP.

Food cobalamin malabsorption: a usual cause of vitamin B12 Arch Intern Med 2000 160:2061-2. Oral Treatment of Pernicious Anemia With High Doses of Vitamin B12 Without Intrinsic Factor. (Ed.) Molecular Nutrition: Vitamins 105-129 Academic Press. The metabolic processes of folic acid and Vitamin B12 J Health Res Rev 2014 1:5-9. Folate and vitamin B12 metabolism: Overview and interaction with riboflavin, vitamin B6, and polymorphisms. National Institutes of Health Office of dietary supplements 1-3 (). Vitamin B12 Deficiency: Recognition and Management. Oral Cyanocobalamin Supplementation in Older People with Vitamin B12 Deficiency: A Dose-Finding Trial.

Eussen SM, de Groot LM, Clarke R, et al.

FAO/WHO expert consultation on human vitamin and mineral requirements.

Oral vitamin B12 Replacement for the Treatment of Pernicious Anemia.

Megaloblastic anemia, a sign of either vita min B12 and/or folate deficiency can be hidden by the ingestion of a large amount of folic acid, but the progressive damage to the nervous system may continue due to the ‘masked’ vitamin B12 deficiency. This dose is more than 200 times higher than the daily recommended dietary allowance for vitamin B12.

#1000 mcg of b12 trial#

However, 1000 mcg daily dosing of cyanocobalamin was able to normalize the MMA concentrations in patients with pernicious anemia.Īnother dose-finding trial study shows that the lowest daily dose of oral cyanocobalamin required to normalize the biochemical markers of mild vitamin B12 deficiency varies from 647-1,032 mcg in the elderly. The oral administration of 25 or 100 mcg of cyanocobalamin every day could only lower but did not normalize the MMA (mean methylmalonic acid) levels. Therefore, methylcobalamin is the least costly form of natural B12 available at present in most of the multivitamins and B-complex formulas. Methylcobalamin supplementation also resulted in 13% more cobalamin storage in the liver than that of cyanocobalamin.Īnother study has also reported lower tissue retention and higher urinary excretion from cyanocobalamin supplements as compared to methyl, hydroxy, and adenosylcobalamin. The natural forms of vitamin B12- methylcobalamin, hydroxocobalamin, and adenosylcobalamin have been commercially available, and are preferred over cyanocobalamin because they are bioidentical forms occurring in human physiology and animal foods.Ī comparative animal study on the effectiveness of methylcobalamin and cyanocobalamin supplementation has reported that urinary excretion of cyanocobalamin was 3 times higher than that of methylcobalamin. However, a recent study demonstrated that 1,000 mcg sublingual cyanocobalamin preparations are sufficient and even superior to 1,000 mcg IM injections of cyanocobalamin. It clearly explains the reason for the equal effectiveness of oral and IM injection of cyanocobalamin.

It has been proved that 69% of 1,000 mcg IM cyanocobalamin has been recovered in the urine after 72 hours, whereas only 27% is found from the same dose of hydroxocobalamin IM injection. Though with limited evidence for satisfactory haematological and neurological responses in patients with vitamin B12 deficiency, both the studies have shown equal efficacy of oral and IM injections. A study has reported the high dose of 2,000 mcg daily oral cyanocobalamin is equal or superior to 1,000 mcg of cyanocobalamin IM injection administered every month for the treatment of vitamin B12 deficiency.Īnother study has concluded that 1,000 mcg of oral cyanocobalamin each day in the beginning, later on the weekly dose and followed by monthly are equally effective as 1,000 mcg of IM cyanocobalamin.